The present review attempts to provide comprehensive information on pharmacology, mechanisms of action, various preclinical and clinical studies, safety precautions and current research prospects of the herb. Buy this article in print. Microcirculatory parameters were shown to be improved as compared to placebo in dose dependent manner, with the higher dose improving symptoms more significantly. The microcirculatory activity of Centella asiatica in venous insufficiency. The extract increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in DNA, protein and collagen content of granulation tissues. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats.
The journal of American science ; 4 3: Chem Pharm Bull Tokyo 49 Crossref. Sign up for new issue notifications. The lower number of circulating endothelial cells was attributed to the protective effect of CATF on vascular intima integrity[ 62 ]. For example, in one study, patients with post phlebetic syndrome PPS showed a greater number of circulating endothelial cells compared to the normal subjects[ 62 ].
In a randomized, double-blind, vehicle-controlled, half-side comparison study, undertaken to determine if it could also improve mild-to-moderate atopic dermatitis asiatiac adults, eighty-eight participants were randomly applied the treatment ointment and the placebo control to either the left or right side of the body for 4 weeks 2 applications per day after which erythema, edema, oozing, and excoriation were assessed[ 72 ].
Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats.
Apart from wound healing, the herb is recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea, fever, amenorrhea, diseases asjatica the female genitourinary tract and also for relieving anxiety and improving cognition. The cognitive impairment was associated with free radical generation in the model in the above study.
PHYTOCHEMICAL ANALYSIS OF CENTELLA ASIATICA L. LEAF EXTRACTS.
Sign up for new issue notifications. The present review attempts to provide comprehensive information ssiatica pharmacology, mechanisms of action, various preclinical and clinical studies, safety precautions and current research prospects of the herb.
Asiaticoside, a constituent in CA, has been reported to possess wound healing activity by increasing collagen formation and angiogenesis[ 1920 ].
The authors concluded that the findings suggested CA’s anxiolytic activity in humans. The efficacy of CA in the treatment of depression, anxiety, and sleep disorders have been tested on small animals and are believed to be associated with its brahmoside and brahminoside constituents or saponin glycosides[ 58 ]. Use of a titrated extract of Centella asiatica in chronic hepatic disorders. A study reported the intracellular activities of an aqueous CAE against herpes simplex viruses, in vitrocontaining both anti HSV-1 and antiHSV-2 activities[ 5455 ].
Ethnomedicinal uses and their scientific validations,-Eurasian J. Chemistry and pharmacology of Centella asiatica: In one study, derivatives of asiatic acid derivatives were shown to exert significant neuroprotective effects on cultured cortical cells by their potentiation of the cellular oxidative defence mechanism.
Phytochemical screening of C. In addition, the contribution of two major single components to the enhanced CREB phosphorylatioin was examined. Digest J Nanomat Biostruct. The isolated steroids from the plant have been used to treat leprosy[ 31 ].
It is now known that angiogenesis plays an important role in wound healing since the newly formed blood vessels help the hypoxic wounds to attain normoxic conditions. In one laboratory animal study, the effects of asiaticoside on antioxidant levels were examined, as antioxidants have been reported to play a role in the wound healing process[ 21 ].
Phytochemical Analysis Of Centella Asiatica L. Leaf Extracts.
In the study, imipramine and total triterpenes from CA reduced the immobility time and ameliorated the imbalance of amino acid levels confirming the antidepressant activity of CA[ 29 ].
The authors concluded that the CA extract presumably strengthened the gastric mucosal barrier and reduced the damaging effects of free radicals. Author concluded that the ulcer protective effect of CAE may be due to strengthening of the mucosal defensive factors[ 42 ]. It has small fan-shaped green leaves with white or light purple-to-pink or white flowers and it bears small oval fruit fig.
The mean MMSE scoring showed significant improvement after administration of CA for 6 months in elderly with mild cognitive impairment MCI at dosage of mg twice a day mg daily.
Plants have been used as treatments for thousands of years, based on experience and folk remedies and continue to draw wide attention for their role in the treatment of mild and chronic diseases. Theoretically, CA was postulated to interfere with blood glucose levels and thus also possibly interfere with the existing hypoglycaemic therapy and cholesterol lowering agents[ 81 ].
In vitromadecassoside was proved to be ineffective in the activation of macrophages caused by lipopolysaccharide[ awiatica ].
Moreover, more double blind randomized clinical trials are needed for investigating its sedative, analgesic, antidepressive, antiviral and immunomodulatory effects that have been demonstrated experimentally in animals.
Therapeutic potential of this plant in terms of its efficacy and versatility is such that further detailed research would appear momentous. Also, it was shown to inhibit the inflammatory process which may provoke hypertrophy in scars and improves the capillary permeability[ 1920 ]. The contents of monoamine neurotransmitters and their metabolites in rats cortex, hippocampus and thalamus were evaluated wherein significant reduction of the corticosterone level and increase of the contents of 5-HT, NE, DA and their metabolites 5-HIAA, MHPG in rat brain were observed which further strengthened the postulated involvement of total triterpenes of CA in ameliorating the function of HPA axis and increasing the contents of monoamine neurotransmitters for its antidepressant effects.
In recent times, focus on plant research has increased all over the world. Dutta T, Basu UP. Quicker and better maturation and cross linking of collagen was observed in the extract-treated rats, as indicated by the high stability of acid-soluble collagen and increase in aldehyde content and tensile strength.