Transcriptional and proteomic analysis reveal recombinant galectins of Haemonchus contortus down-regulated functions of goat PBMC and modulation of several signaling cascades in vitro. The negative predictive value was found to be All the patients of any age and either gender having goitre requiring surgery were included. Patients with multinodular goitre and who were hypothyroid or hyperthyroid were excluded from the study. The finding is consistent with the study of Aiad et al. Distribution of cases as per sex Click here to view.

Nodules are more frequent in females and are mostly benign. Backward and forward movements were used under constant suction with the needle moved at different depths and angles within the confines of the nodule. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The findings are consistent with findings of other studies 16 , 17 who reported that size of nodule and interval of growth of nodule are not helpful for predicting or excluding thyroid malignancy. For the retrospective arm, enough information was extracted as much as possible from the cytology and histopathology reports.

Sample size was estimated using the formula for single proportions 8.

Collections Thesis – Masters [] Pathology collection – Dunedin [56]. Incidental cancer in patients surgically treated for benign thyroid disease. The diagnostic accuracy of Correlation between FNAC diagnosis and final histological diagnosis, intraoperative frozen section diagnoses without intraoperative cytology and final histological diagnoses, and intraoperative frozen section diagnoses associated with intraoperative cytology and final histological diagnoses were J Clin Endocrinol Metab.


thyroid fnac thesis

World J Endoc Surg. Diagnostic accuracy of fine needle aspiration cytology in thyroid lesions: The female to male F: All the patients presented with solitary thyroid nodule.

Fine needle aspiration cytology is a simple, easy to perform, cost effective, and easily repeated procedure for the diagnosis of thyroid cancer. These reporting schedules were least informative due to variability of sensitivity and least reproducibility. The categorization of the smears after fnacc diagnosis was done in accordance with The Bethesda System for reporting thyroid cytopathology.

On histological examination of the resected nodules there were Galectin-3immunomarker is considerably expressed in malignant tumors, but it is not expressed in benign follicular lesions. Ethical consideration Before the start of this study, ethical clearance was obtained from the Institutional Review Board of Makerere University College of Health Sciences.

Journal of Thyroid Research

Clinical and histopathological patterns. The many pathologists involved in reporting histopathology could have over-estimated or under-estimated malignancy rate random error.

Written informed consent was obtained from patients both for the surgery and for inclusion in the study. Monitoring the severity of iodine deficiency disorders in Uganda. The ethical committee of the University of Health Sciences, Lahore, approved the study protocol.

In a related study in Uganda, FTC predominated at The aspirated material was smeared on a slide labelled thyrod the patient’s laboratory number and another labelled slide was placed on the smear to evenly and thinly spread it between the thyrodi slides on pulling them apart, this made two smears per pass and therefore four smears per patient.


The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer

Overall, median age IQR was 42 years 34—5092 females and 7 males with a female to male ratio of Patients who underwent clinical and laboratory evaluation and thyroidectomy at Mulago National Referral hospital and the Pathology department of Makerere University College of Health Sciences were consecutively recruited over a four months period. Malignancy was noted in 13 Moreover, diagnostic accuracy of Galectin-3staining was The false positive rate was The choline content rises in malignancy because of rapid multiplication and proliferation of cells The difference could probably be attributed to the fact that a significant proportion of long standing multinodular goiter in areas endemic for iodine deficiency tend to undergo malignant transformation Table 2 Baseline clinical characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm.

thyroid fnac thesis

Results In total, 99 patients were recruited, the F: J Egyptian Natl Canc Inst. Please review our privacy policy.

thyroid fnac thesis

Journal of the Egyptian National Cancer Institute. Based on the cytology findings, patients can be followed in cases of benign diagnosis thess subjected to surgery in cases of malignant diagnosis thereby decreasing the rate of unnecessary surgery. Table-II Expression of Galectin-3 staining in different histologic lesions.